Pharmaceutical intermediate
Tirzepatide
Tirzepatide: A Novel Dual Receptor Agonist for Diabetes and Obesity Management
Tirzepatide is a new once-weekly injectable medication designed primarily to improve glycemic control in individuals with type 2 diabetes. By activating both the glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors, Tirzepatide offers a dual mechanism of action that not only lowers blood glucose levels but also promotes weight loss.
Unique Mechanism of Action
Tirzepatide is a 39-amino-acid synthetic peptide that integrates elements from both GIP and GLP-1 molecules. It binds to both GIP and GLP-1 receptors, mimicking the physiological effects of these two incretin hormones. Activation of the GIP receptor enhances insulin secretion, while activation of the GLP-1 receptor helps suppress appetite and reduce food intake. Additionally, Tirzepatide’s acylation modification extends its half-life, enabling a convenient once-weekly dosing regimen.
Clinical Efficacy
Clinical trials have demonstrated Tirzepatide’s significant efficacy in glycemic control and weight reduction. For instance, a Phase 3 clinical trial showed that Tirzepatide can reduce HbA1c levels by up to 2.58% and body weight by 5.4 to 11.7 kilograms. Moreover, Tirzepatide has shown promise in reducing heart failure-related risks in patients with heart failure with preserved ejection fraction (HFpEF).
Safety and Tolerability
Common adverse effects of Tirzepatide include gastrointestinal discomfort, such as nausea, vomiting, and diarrhea. However, these side effects typically diminish with dose adjustment, and the risk of hypoglycemia is low. Overall, Tirzepatide has a favorable safety profile and is suitable for long-term use.
Other uses
Beyond diabetes and obesity, Tirzepatide is also being explored for the treatment of non-alcoholic steatohepatitis (NASH), chronic kidney disease (CKD), and obstructive sleep apnea (OSA). Its broad clinical application potential and innovative mechanism position Tirzepatide as a significant breakthrough in the management of metabolic diseases.
Tirzepatide, with its unique dual receptor agonism, offers a new therapeutic option for type 2 diabetes and obesity. Its clinical trial outcomes and potential for widespread application make it a promising direction for the future treatment of metabolic disorders.
SPECIFICATION
| Product name | Tirzepatide |
| Other Names | GIPGLP-1 |
| CAS No. | 2023788-19-2 |
| MF | C225H348N48O68 |
| Appearance | White powder |
| Packaging | 10mg-80mg/vials/cartridges |
Packaging
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Logistics and Payment
Chengdu Yurong Chemical Co., Ltd. is a supplier of hypophosphorous acid, and hypophosphorous acid is also one of our best-selling products. Our company cooperates with many logistics companies and offers a variety of logistics methods to choose from. Fast delivery and short transportation cycle.
FAQ
1. Can I get a sample before placing an order?
Yes, we can supply the free sample, but the shipping cost is paid by our clients.
2. Can you supply the relevant documentation?
Yes, we can provide most documentation including Certificates of Analysis / Conformance; Insurance; Origin, and other export documents where required.
3. What is the average lead time?
Our lead time is within 7 days for samples and most products ordered in quantities under 1,000 kg. For bulk production, please contact our customer service to discuss lead times.
4. Do you guarantee safe and secure delivery of products?
Yes, we always use safe and high - quality export packaging. For sensitive goods, we use discreet packaging. We also support customization and DDP door - to - door shipping services.
5. How about the shipping fees?
The shipping cost depends on the way you choose to get the goods. Express is normally the most quickest but also most expensive way. By seafreight is the best solution for big amounts. Exactly freight rates we can only give you if we know the details of amount, weight and way. Please contact us for further information.